Simultaneous Spectrophotometric Estimation of amlodipine besylate and Perindopril Erbumine in tablet Formulation

Two simple, precise, accurate, specific and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Amlodipine Besylate and Perindopril Erbumine in combined tablet dosage form using simultaneous equation and first order derivative methods. In method A (simultaneous equation method) Amlodipine Besylate and Perindopril Erbumine have absorbance maxima at 235 nm and 210 nm respectively in methanol. Method B involves first order derivative spectroscopy, 220 nm was selected for the estimation of Amlodipine Besylate which is zero crossing for Perindopril Erbumine whereas 240 nm selected for the estimation of Perindopril Erbumine which is zero crossing for Amlodipine Besylate. The developed methods were found to be accurate, precise and reproducible and have been validated statistically.