ScholarLens Back to search
2017•Revista de ChimieOpen access

Oxidative Stress Markers in Chemically Induced Oral Premalignant Lesions

Ioana Scrobotă, Grigore Băciuț, Roxana Buzatu, Camelia Alexandrina Szuhanek, Liana Todor, Silviu Valentin Vlad, Pompei Bolfă, Horia Câlniceanu

Open full text 0 citations

Abstract

In our study we induced oral premalignant lesions using 4 nitro-quinoline-1-oxide (4NQO) topically applied on oral mucosa for 24 weeks. We detected an oxidative stress marker malondialdehyde (MDA) significantly increased (p[0.05) and an antioxidant/detoxifying activity marker, glutathione (GSH), significantly decreased (p[0.05) in the oral induced epithelial dysplasias. We appreciated that issue MDA and GSH could serve as diagnostic, screening and evaluation of response to therapy tools in oral premalignacy.

About this research paper

What this paper is about

In our study we induced oral premalignant lesions using 4 nitro-quinoline-1-oxide (4NQO) topically applied on oral mucosa for 24 weeks. We detected an oxidative stress marker malondialdehyde (MDA) significantly increased (p[0.05) and an antioxidant/detoxifying activity marker, glutathione (GSH), significantly decreased (p[0.05) in the oral induced epithelial dysplasias. We appreciated that issue MDA and GSH could serve as diagnostic, screening and evaluation of response to therapy tools in oral premalignacy.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

In our study we induced oral premalignant lesions using 4 nitro-quinoline-1-oxide (4NQO) topically applied on oral mucosa for 24 weeks. We detected an oxidative stress marker malondialdehyde (MDA) significantly increased (p[0.05) and an antioxidant/detoxifying activity marker, glutathione (GSH), significantly decreased (p[0.05) in the oral induced epithelial dysplasias. We appreciated that issue MDA and GSH could serve as diagnostic, screening and evaluation of response to therapy tools in oral premalignacy.

Key concepts: Malondialdehyde, Oxidative stress, Glutathione, Antioxidant, Oral mucosa, Chemistry, Medicine, Pharmacology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Oxidative Stress Markers in Chemically Induced Oral Premalignant Lesions — Research Paper | ScholarLens