1999•OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)Requires access
In Vivo Boron Uptake Determination for Boron Neutron Capture Synovectomy
Emanuela Binello, Sonya Shortkroff, J. C. Yanch
Open publisher page 3 citations
Abstract
Boron neutron capture synovectomy (BNCS) has been proposed as a new application of the boron neutron capture reaction for the treatment of rheumatoid arthritis. In BNCS, a boron compound is injected into the joint space, where it is taken up by the synovium. The joint is then irradiated with neutrons of a desired energy range, inducing the boron neutron capture reaction in boron-loaded cells. Boron uptake by the synovium is an important parameter in the assessment of the potential of BNCS and in the determination of whether to proceed to animal irradiations for the testing of therapeutic efficacy. We present results from an investigation of boron uptake in vivo by the synovium.