Effect of add‐on administration of kamikihito with donepezil monotherapy in a patient with Alzheimer's disease

ABSTRACT Case A 69‐year‐old male presented with a two‐year history of memory decline. Results of his cognitive function tests suggested cognitive impairment and brain magnetic resonance imaging showed cortical atrophy, predominantly in the temporal lobes. Based on these findings, he was diagnosed with Alzheimer's disease. Outcome Although treatment with donepezil was commenced, the patient's cognitive function deteriorated in the year after initiation. However, his cognitive impairment improved in the year after add‐on administration of kamikihito, a traditional Japanese herbal medicine, with donepezil monotherapy. Conclusion Combination therapy with donepezil and kamikihito seems to be beneficial and worth considering for patients who are secondarily non‐responsive to donepezil monotherapy.