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The many faces of two closely related tauopathies : progressive supranuclear palsy and corticobasal degeneration

Tamás Révész

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Abstract

The five studies forming this thesis deal with two closely related neurodegenerative diseases,progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), both of which are characterised by abundant tau-positive neuronal and glial filamentous inclusions and by \nshared genetic risk factors[19, 70]. Four studies focus on demonstrating neuropathological, biochemical and genetic differences between the classical/typical form and atypical PSP while the fifth study discusses issues relevant for understanding disease progression in CBD. \n

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The five studies forming this thesis deal with two closely related neurodegenerative diseases,progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), both of which are characterised by abundant tau-positive neuronal and glial filamentous inclusions and by \nshared genetic risk factors[19, 70]. Four studies focus on demonstrating neuropathological, biochemical and genetic differences between the classical/typical form and atypical PSP while the fifth study discusses issues relevant for understanding disease progression in CBD. \n

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Available abstract

The five studies forming this thesis deal with two closely related neurodegenerative diseases,progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), both of which are characterised by abundant tau-positive neuronal and glial filamentous inclusions and by \nshared genetic risk factors[19, 70]. Four studies focus on demonstrating neuropathological, biochemical and genetic differences between the classical/typical form and atypical PSP while the fifth study discusses issues relevant for understanding disease progression in CBD. \n

Key concepts: Progressive supranuclear palsy, Corticobasal degeneration, Neuroscience, Degeneration (medical), Tau pathology, Pathology, Disease, Psychology

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