2020•Infection and ImmunityOpen access
Nasal Delivery of a Commensal Pasteurellaceae Species Inhibits Nontypeable Haemophilus influenzae Colonization and Delays Onset of Otitis Media in Mice
Caitlyn Granland, Naomi M. Scott, Jean‐François Lauzon‐Joset, Jeroen D. Langereis, Camilla de Gier, Katrien M. J. Sutherland, Sharon Clark, Janessa Pickering, Ruth B. Thornton, Peter Richmond, Deborah H. Strickland, Lea‐Ann S. Kirkham
Open full text 15 citations
Abstract
Nasopharyngeal colonization with nontypeable Haemophilus influenzae (NTHi) is a prerequisite for developing NTHi-associated infections, including otitis media. Therapies that block NTHi colonization may prevent disease development. We previously demonstrated that Haemophilus haemolyticus , a closely related human commensal, can inhibit NTHi colonization and infection of human respiratory epithelium in vitro . We have now assessed whether Muribacter muris (a rodent commensal from the same family) can prevent NTHi colonization and disease in vivo using a murine NTHi otitis media model.