2020•Antimicrobial Agents and ChemotherapyOpen access

Subinhibitory Concentrations of Mupirocin Stimulate Staphylococcus aureus Biofilm Formation by Upregulating cidA

Ye Jin, Yinjuan Guo, Qing Zhan, Yongpeng Shang, Di Qu, Fangyou Yu

Abstract

Previous studies have shown that the administration of antibiotics at subinhibitory concentrations stimulates biofilm formation by the majority of multidrug-resistant Staphylococcus aureus (MRSA) strains. Here, we investigated the effect of subinhibitory concentrations of mupirocin on biofilm formation by the community-associated (CA) mupirocin-sensitive MRSA strain USA300 and the highly mupirocin-resistant clinical S. aureus SA01 to SA05 isolates.

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Available abstract

Key concepts: Mupirocin, Staphylococcus aureus, Microbiology, Biofilm, Antibiotics, Micrococcaceae, Staphylococcal infections, Daptomycin