2009•Zhonghua zhongyiyao zazhiRequires access
Experimental study on effect of Ele-acupuncture on cognitive impairment of Alzheimer's disease model rats.
Liu Zhi-yan, Juan Liu, Hongyan Qu
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Abstract
Objective:Through animal experiments to observe the behavior and serum malondialdehyde(MDA)and total antioxidative capacity(T-AOC)content after electro-acupuncture Baihui,Fengfu,Shenshu,Xuanzhong Point of Alzheimer, s disease in rat.Method:Select forty Healthy adult Wistar rats,the Wistar rats were randomly divided into four groups,model group,electro-acupuncture group,western medicine group,electro-acupuncture and western medicine group.Abdominal cavity injection of D-galactose in order to prepare the Alzheimer, s disease model rats.Electro-acupuncture group:acupuncture Baihui,Shenshu, Fengfu,Xuanzhong.Western medicine group:Piracetan intragastric administration one times a day.Every other day give the fixed and crawl for ten minutes.Electro-acupuncture and western medicine group:Accupuncture treatment and drug treatment are above all.Model group:Every day give the same fixed and crawl as electro-acupuncture group.Behavior and serum MDA,T-AOC levels tested after treatment.Results:electro-acupuncture group,electro-acupuncture and western medicine group could extend the incubation period,reduce the number of errors(P0.05).lower the serum MDA and increase the T-AOC content(P0.05). Conclusion:electro-acupuncture Baihui,Fengfu,Shenshu,Xuanzhong could extend the incubation period,reduce the number of errors.lower the serum MDA and increase the T-AOC content.The mechanism may be enhanced the function of oxygen free radical scavenging system,improve the ability of antioxidation.