2009•STM:n Hallinnonalan avoin julkaisuarkisto (Julkari)Requires access
Long-Term Outcome Associated with Early Repolarization on Electrocardiography
Jani T. Tikkanen, Olli Anttonen, Juhani Junttila, Aapo L. Aro, Tuomas Kerola, Harri Rissanen, Antti Reunanen, Heikki V. Huikuri
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Abstract
Background Early repolarization, which is characterized by an elevation of the QRS–ST junction (J point) in leads other than V1 through V3 on 12-lead electrocardiography, has been associated with vulnerability to ventricular fibrillation, but little is known about the prognostic significance of this pattern in the general population. Methods We assessed the prevalence and prognostic significance of early repolarization on 12-lead electrocardiography in a community-based general population of 10,864 middle-aged subjects (mean [±SD] age, 44±8 years). The primary end point was death from cardiac causes, and secondary end points were death from any cause and death from arrhythmia during a mean follow-up of 30±11 years. Early repolarization was stratified according to the degree of J-point elevation (≥0.1 mV or >0.2 mV) in either inferior or lateral leads. Results The early-repolarization pattern of 0.1 mV or more was present in 630 subjects (5.8%): 384 (3.5%) in inferior leads and 262 (2.4%) in lateral leads,...