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2020•Journal of Clinical MicrobiologyOpen access

Test Accuracy of Human Papillomavirus in Urine for Detection of Cervical Intraepithelial Neoplasia

Eliane Rohner, Lisa Rahangdale, Busola Sanusi, Andrea K. Knittel, Laurence M. Vaughan, Kirsty L. Chesko, Brian Faherty, Samantha E. Tulenko, John W. Schmitt, LaHoma Smith Romocki, Vijay Sivaraman, Julie A. Nelson, Jennifer S. Smith

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Abstract

cutoff value of ≤40, 90% sensitivity was achieved for urine-based hrHPV testing. Agreement between results for urine samples and self-collected cervicovaginal samples (kappa = 0.58) or provider-collected cervical samples (kappa = 0.54) was moderate. Urine-based hrHPV testing may be a promising approach to improve cervical cancer screening coverage, especially among women with limited access to health care.

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What this paper is about

cutoff value of ≤40, 90% sensitivity was achieved for urine-based hrHPV testing. Agreement between results for urine samples and self-collected cervicovaginal samples (kappa = 0.58) or provider-collected cervical samples (kappa = 0.54) was moderate. Urine-based hrHPV testing may be a promising approach to improve cervical cancer screening coverage, especially among women with limited access to health care.

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Available abstract

cutoff value of ≤40, 90% sensitivity was achieved for urine-based hrHPV testing. Agreement between results for urine samples and self-collected cervicovaginal samples (kappa = 0.58) or provider-collected cervical samples (kappa = 0.54) was moderate. Urine-based hrHPV testing may be a promising approach to improve cervical cancer screening coverage, especially among women with limited access to health care.

Key concepts: Colposcopy, Cervical intraepithelial neoplasia, Human papillomavirus, Medicine, Urine, Gynecology, Cervical screening, Papillomaviridae

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