ScholarLens Back to search
2020•Chemistry - An Asian JournalRequires access

Synthesis of Sulfamate‐Fused 2‐Aminopyrroles via an Isocyanide‐Based Three Component [1+2+2] Annulation

Chuan‐Chuan Wang, Zhiwei Ma, Ya‐Li Qu, Zhi‐Jing Liu, Xiao‐Pei Chen, Jing Zhou, Yajing Chen

Open publisher page 26 citations

Abstract

An efficient preparation of sulfamate-fused 2-aminopyrroles was achieved through an isocyanide-based three-component [1+2+2] annulation of isocyanides, dialkyl acetylenedicarboxylates, and sulfamate-derived cyclic imines in good to excellent yields (up to 99 %). This reaction proceeds smoothly without any activation or modification of substances under neutral and metal-free conditions. The reaction could also be conveniently performed on a gram scale.

About this research paper

What this paper is about

An efficient preparation of sulfamate-fused 2-aminopyrroles was achieved through an isocyanide-based three-component [1+2+2] annulation of isocyanides, dialkyl acetylenedicarboxylates, and sulfamate-derived cyclic imines in good to excellent yields (up to 99 %). This reaction proceeds smoothly without any activation or modification of substances under neutral and metal-free conditions. The reaction could also be conveniently performed on a gram scale.

Why it matters

OpenAlex reports 26 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

An efficient preparation of sulfamate-fused 2-aminopyrroles was achieved through an isocyanide-based three-component [1+2+2] annulation of isocyanides, dialkyl acetylenedicarboxylates, and sulfamate-derived cyclic imines in good to excellent yields (up to 99 %). This reaction proceeds smoothly without any activation or modification of substances under neutral and metal-free conditions. The reaction could also be conveniently performed on a gram scale.

Key concepts: Annulation, Isocyanide, Chemistry, Combinatorial chemistry, Component (thermodynamics), Organic chemistry, Catalysis, Thermodynamics

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Synthesis of Sulfamate‐Fused 2‐Aminopyrroles via an Isocyanide‐Based Three Component [1+2+2] Annulation — Research Paper | ScholarLens