Mechanism of resistance and therapeutic prospect of leukemia mediated by signaling pathway in bone marrow microenvironment.

Leukemia is a malignant disease of the blood system. Although the current research on the pathogenesis of leukemia is more and more in-depth and has an influential guiding significance for the ongoing clinical treatment of leukemia, its resistance and recurrence is still a challenging problem that needs to be solved. At present, several studies have indicated that the bone marrow microenvironment played an essential role in drug resistance of leukemia, forming a protective spot for them by interacting with leukemic cells, offering protective effects of leukemia cells from cytotoxic drugs. The bone marrow microenvironment can mediate the development of drug resistance in leukemia through many signal pathways, by affecting the growth, propagation, and apoptosis of leukemia cells. The microenvironment can promote cell survival, proliferation, and anti-apoptosis, and then mediate the drug resistance of leukemia. It is considered as a better guidance of clinical treatment by understanding the drug resistance mechanism of leukemia.