2018•PubMedRequires access

[Comparison of epidermal growth factor receptor (EGFR) gene T790M mutation by droplet digital PCR and Super-ARMS PCR in plasma ctDNA samples of non-small cell lung cancer patients with the resistance to EGFR-tyrosine kinase inhibitor].

Zhen Cao, Wen‐Chi Wu, Likun Hou, W Zhang, Chanchan Gao, Chuanxin Wu, Longyu Zhang

Abstract

While a significant correlation between the two methods is shown. ddPCR is more sensitive than Super-ARMS in the detection of EGFR T790M mutation, indicating that it is a better method in guiding target drug therapy of non-small cell lung cancer patients after acquiring the resistance to EGFR-TKI.

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Key concepts: T790M, Digital polymerase chain reaction, Lung cancer, Mutation, Epidermal growth factor receptor, Medicine, Gene mutation, Resistance mutation