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[Effect of carbidine on the content and storage of adrenergic neurotransmitter in the synaptic vesicles].

Arefolov Va, Panasiuk Lv

Abstract

The influence of carbidine, an original psychotropic drug, on the adrenergic neurotransmitter content and storage in the sympathetic nerves was studied with the use of cytochemical electron microscopy. The influence of carbidine on the uptake of the exogenous noradrenaline (NA) in the synaptic vesicles was also studied. Carbidine was found to be capable to decreasing the NA storage in the synaptic vesicles and failed to block the accumulation of the exogenous NA in the synaptic vesicles.

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Key concepts: Synaptic vesicle, Neurotransmitter, Vesicle, Adrenergic, Chemistry, Synaptic augmentation, Norepinephrine, Biophysics