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[INFLUENCE OF NITRIC OXIDE AND ALPHA-TOCOPHEROL ON STRUCTURAL CHANGES IN PLACENTA DURING VIOLATION OF UTEROPLACENTAL CIRCULATION IN WHITE RATS].

Ivanova As, Peretyat'ko Lp, Demidov Vi, С. Б. Назаров

Abstract

We have studied the effect of nitric oxide and alpha-tocopherol on morphological changes in the placenta of white rats during pregnancy complicated by disorders of the uterine and placental circulation. Violation of the uteroplacental circulation was reproduced by the method of M. M. Vartanova (1984). In white rats with violated uteroplacental blood circulation, the use of L-arginine methyl ester compensates for disturbances of the fetoplacental blood flow. It is established that an increase in nitric oxide and the inhibition of free radical processes in the placenta of experimental animals under conditions of artificially created pathology of pregnancy belong to pathogenetic rather than sanogenetic factors.

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Key concepts: Placenta, Placental Circulation, Nitric oxide, Blood flow, Endocrinology, Internal medicine, Pregnancy, Fetus