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2019•International Research Journal of PharmacyOpen access

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC AND RP-HPLC METHOD FOR METOPROLOL SUCCINATE

Shoaeb Mohammad Syed, RAJENDRA P. MARATHE, Paresh R. Mahaparale

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Abstract

The aim of recent study was to develop a combined UV Spectrophotometric method and RP-HPLC method for metoprolol succinate, UV Spectrophotometric method was performed at 270 nm and samples were prepared with phosphate buffer solution pH 6.8, RP-HPLC method was performed using Alligent-1100 C18 column (Chemstation-32 software) at 30 0 c with flow rate of 1.0 ml/min.at detection wavelength of 215 nm.Both the methods were validated as per ICH guidelines and various validation parameters like accuracy, precision, LOD, LOQ, recovery study and range were determined.The proposed methods were simple, rapid, precise, and accurate, and can be used for routine analysis of metoprolol succinate in bulk and combinations.

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The aim of recent study was to develop a combined UV Spectrophotometric method and RP-HPLC method for metoprolol succinate, UV Spectrophotometric method was performed at 270 nm and samples were prepared with phosphate buffer solution pH 6.8, RP-HPLC method was performed using Alligent-1100 C18 column (Chemstation-32 software) at 30 0 c with flow rate of 1.0 ml/min.at detection wavelength of 215 nm.Both the methods were validated as per ICH guidelines and various validation parameters like accuracy, precision, LOD, LOQ, recovery study and range were determined.The proposed methods were simple, rapid, precise, and accurate, and can be used for routine analysis of metoprolol succinate in bulk and combinations.

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Available abstract

The aim of recent study was to develop a combined UV Spectrophotometric method and RP-HPLC method for metoprolol succinate, UV Spectrophotometric method was performed at 270 nm and samples were prepared with phosphate buffer solution pH 6.8, RP-HPLC method was performed using Alligent-1100 C18 column (Chemstation-32 software) at 30 0 c with flow rate of 1.0 ml/min.at detection wavelength of 215 nm.Both the methods were validated as per ICH guidelines and various validation parameters like accuracy, precision, LOD, LOQ, recovery study and range were determined.The proposed methods were simple, rapid, precise, and accurate, and can be used for routine analysis of metoprolol succinate in bulk and combinations.

Key concepts: Metoprolol, Chromatography, Chemistry, High-performance liquid chromatography, Medicine, Internal medicine

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DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC AND RP-HPLC METHOD FOR METOPROLOL SUCCINATE — Research Paper | ScholarLens