2007•PubMedRequires access

The effect of hydrophilic base on pharmaceutical availability of prednisolone complexed with beta-cyclodextrin.

Maria Szcześniak, Aleksander A Kubis, Janusz Pluta

Abstract

Studies on the effect of hydrophilic gel composition on pharmaceutical availability of prednisolone complexed with beta-cyklodextrin at P:beta-CD ratios 1:1 and 1:2 revealed that the half-release times were shortened and differentiated depending on the substances added hydrogel to propylene glycol, dimethylacetamide and polysorbate 20 in comparison to preparations containing non-complexed active substance.

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Available abstract

Key concepts: Chemistry, Polyvinyl alcohol, Prednisolone, Cyclodextrin, Beta-Cyclodextrins, BETA (programming language), Excipient, Chromatography