LIPID PROFILE OF ALLOXAN-INDUCED DIABETIC WISTAR RATS TREATED WITH METHANOLIC EXTRACT OF ADANSONIA DIGITATA FRUIT PULP

This study was carried out to assess the antidiabetic properties of Adansoniadigitata fruit pulp by evaluating the effect of its methanolic extract (MAD) on cholesterol, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL) and triglycerides. Forty eight male wistar/albino rats weighing 160 to 240 g were randomly distributed into six treatment groups [Group1, Normal control, each given only 0.2 ml distilled water daily for 4 weeks; Group 2, diabetes control rats, induced with 150 mg/kg b.w., i.p. administration of alloxan and thereafter given 0.2 ml distilled water throughout the study period; Groups 3, 4 and 5, diabetic (i.p., 150 mg/kg b.w. alloxan) rats were given single oral dose of MAD (100, 200 and 300 mg/kg b.w. respectively) for 4 weeks; Group 6, diabetic rats (i.p., 150 mg/kg b.w. alloxan) were treated with 84 mg/kg b.w. of Chloropropamide, once daily for 4 weeks]. The serum concentration of cholesterol, HDL, LDL and triglycerides of all the animals in each group were determined after the 14th and 28th treatment. There was significant (P<0.001) reduction of serum cholesterol, LDL and Triglycerides when compared with the diabetic control rats. These reductions were dose dependent and compared well with values obtained in the standard drug control group. Significant (P<0.001) increase in HDL were seen in the MAD experimental groups but differed significantly (P<0.001) with reduction seen in chloropropamide group. Keywords : Antidiabetic property, Adansoniadigitata fruit pulp, Lipid profile, Wistar Rats