2010•Zhongguo jiaqinRequires access

Immunopotentiation of Recombinant Chicken Interleukin-2 on Avian Influenza Inactivated Vaccine

Niu Ze, Xiaofeng Ren, Yan Zeng, Ming Liu, Lu ChunYing, Li GuangXing

Abstract

The purpose of the study was to evaluate immune effect of recombinant chicken interleukin-2(IL-2) on an inactivated vaccine against H5N1 subtype avian influenza.The recombinant IL-2 protein and avian influenza inactivated vaccine were used as immunogens to immunize 14-day-age specific pathogen free (SPF) chickens.The titers of serum antibody against avian influenza virus and the number of spleen T-lymphocyte subsets were measured at one-week interval.In addition,the protection rate of the vaccine to the chickens post-challenge was calculated.The results indicated that recombinant IL-2 enhanced the serum antibody titers significantly and increased the spleenic T-lymphocyte CD4+ and CD8+ cells of immunized chickens.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Virology, Influenza A virus subtype H5N1, Recombinant DNA, Inactivated vaccine, Biology, Titer, Antibody, Immune system