2019•Leukemia & lymphoma/Leukemia and lymphomaRequires access

Characterization of a cryptic PML-RARA fusion by mate-pair sequencing in a case of acute promyelocytic leukemia with a normal karyotype and negative RARA FISH studies

Matthew Schultz, Patrick R. Blackburn, Christopher H. Cogbill, Beth A. Pitel, James B. Smadbeck, Sarah H. Johnson, George Vasmatzis, Karen L. Rech, William R. Sukov, Patricia T. Greipp, Nicole L. Hoppman, Linda B. Baughn, Rhett P. Ketterling, Jess F. Peterson

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Abstract

Acute promyelocytic leukemia (APL) is a time-critical hematologic neoplasm that is amenable to targeted therapy [1]. While the diagnosis of APL can be suspected based on the clinical presentation, ...

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Key concepts: Acute promyelocytic leukemia, Karyotype, Leukemia, Chromosomal translocation, Biology, Cancer research, Acute leukemia, Fish <Actinopterygii>