2018•PubMedOpen access

[Effects of adipose-derived stem cell released exosomes on proliferation, migration, and tube-like differentiation of human umbilical vein endothelial cells].

Jing Zhang, Yangyan Yi, Shuifa Yang, Yuanzheng Zhu, Xuan Hu

Abstract

Objective: To explore the effects of adipose-derived stem cell released exosomes (ADSC-Exos) on the proliferation, migration, and tube-like differentiation of human umbilical vein endothelial cells (HUVECs). Methods: was observed in BALB/c male nude mice via the injection of HUVECs and Matrigel with or without ADSC-Exos. After 2 weeks, the neovascularization in Matrigel was measured and mean blood vessel density (MVD) was calculated. The above experiments were all controlled by the same amount of PBS. Results: =0.000). Conclusion: .

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Key concepts: Matrigel, Umbilical vein, Adipose tissue, Chemistry, Mesenchymal stem cell, Stem cell, Flow cytometry, Human umbilical vein endothelial cell