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2019•PubMedRequires access

[Research progress of pyroptosis in sepsis].

Lingzhi Shen, Li Li, Jing Yan

Open publisher page 8 citations

Abstract

OBJECTIVE: Sepsis is an organ dysfunction syndrome caused by an abnormal host immune response because of infection. Pyroptosis is a newly discovered programmed cell death relies on caspase-1, caspase-11, caspase-4, caspase-5 and is characterized by the release of inflammatory cytokines interleukin-1β (IL-1β) and IL-18. The exploration of the molecular mechanisms of pyroptosis and the correlation between pyroptosis and sepsis can provide new ideas and new targets for the treatment of sepsis.

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What this paper is about

OBJECTIVE: Sepsis is an organ dysfunction syndrome caused by an abnormal host immune response because of infection. Pyroptosis is a newly discovered programmed cell death relies on caspase-1, caspase-11, caspase-4, caspase-5 and is characterized by the release of inflammatory cytokines interleukin-1β (IL-1β) and IL-18. The exploration of the molecular mechanisms of pyroptosis and the correlation between pyroptosis and sepsis can provide new ideas and new targets for the treatment of sepsis.

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OpenAlex reports 8 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

OBJECTIVE: Sepsis is an organ dysfunction syndrome caused by an abnormal host immune response because of infection. Pyroptosis is a newly discovered programmed cell death relies on caspase-1, caspase-11, caspase-4, caspase-5 and is characterized by the release of inflammatory cytokines interleukin-1β (IL-1β) and IL-18. The exploration of the molecular mechanisms of pyroptosis and the correlation between pyroptosis and sepsis can provide new ideas and new targets for the treatment of sepsis.

Key concepts: Pyroptosis, Sepsis, Medicine, Caspase 1, Inflammasome, Immunology, Programmed cell death, Caspase

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