Triple Negative Breast Cancer, Clinicopathologic Study of Egyptian Patients, NCI Experience

Background: Triple negative breast cancer category is a challenging group of breast cancer. It needs more detailed clinical and pathological studies.Aim of Study: To study the clinicopathologic characteristics of triple-negative breast cancer of Egyptian patients.Patients and Methods: A retrospective study was done included 59 women with triple negative breast cancer collected from Pathology Department at NCI, Cairo University, Egypt. Clinical data and pathological data were revised, then follow-up of the cases with a median follow-up time 40.5 months (range: 8-67).Results: Most cases were equal or below 50 years old, post-menopausal, and unilateral. According to pathological characters, majority of cases represented grade 2, T2, positive lymph nodes, and stage 2. As regards outcome three cases underwent recurrence, seven cases underwent metastasis, and two cases show metastasis and recurrence. At the end of the study 44 cases were alive, ten died, and five show lost follow-up. There was a significant relationship found between grade and DFS, as well as OS with grade, stage, occurrence of metastasis and node positivity.Conclusion: Triple negative breast cancer group were more noticed among age group less than 50 years, with tendency to express high grade, large tumor size, high stage and node positivity, with significant relationship between grade and DFS, as well as OS with grade, stage, occurrence of metastasis and node positivity.