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2015•Unpublished venueOpen access

Author response: Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

Carmela Sidrauski, Jordan C. Tsai, Martin Kampmann, Brian R. Hearn, P. Vedantham, Priyadarshini Jaishankar, Masaaki Sokabe, Aaron S. Mendez, Billy W. Newton, Edward L Tang, Erik Verschueren, Jeffrey R. Johnson, Nevan J. Krogan, Christopher S. Fraser, Jonathan S. Weissman, Adam R. Renslo, Peter Walter

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Abstract

A drug-like molecule called ISRIB, which activates the translation initiation factor eIF2B, antagonizes stress responses as diverse as protein misfolding and nutrient deprivation, and restores protein synthesis, enhancing memory.

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What this paper is about

A drug-like molecule called ISRIB, which activates the translation initiation factor eIF2B, antagonizes stress responses as diverse as protein misfolding and nutrient deprivation, and restores protein synthesis, enhancing memory.

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Available abstract

A drug-like molecule called ISRIB, which activates the translation initiation factor eIF2B, antagonizes stress responses as diverse as protein misfolding and nutrient deprivation, and restores protein synthesis, enhancing memory.

Key concepts: Integrated stress response, eIF2, Translation (biology), Protein subunit, Biology, Computational biology, Bioinformatics, Cell biology

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