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2018•PubMedOpen access

[Dexmedetomidine alleviates postoperative cognitive dysfunction in aged rats probably via silent information regulator 1 pathway].

Sitong Fang, Yong Chen, Peng Yao, Yiling Li, Yujun Yang, Guohai Xu

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Abstract

OBJECTIVE: To explore the role of silent information regulator 1 (SIRT1) signaling pathway in mediating the effect of dexmedetomidine (DEX) to alleviate postoperative cognitive dysfunction (POCD) in aged rats. METHODS: ) and interleukin-6 (IL-6) using ELISA; Western blotting was used to detect the expression of SIRT1 and nuclear factor- κB (NF-κB) in the hippocampal neurons. RESULTS: < 0.05). CONCLUSIONS: DEX alleviates POCD in aged rats probably via SIRT1 signaling pathway.

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What this paper is about

OBJECTIVE: To explore the role of silent information regulator 1 (SIRT1) signaling pathway in mediating the effect of dexmedetomidine (DEX) to alleviate postoperative cognitive dysfunction (POCD) in aged rats. METHODS: ) and interleukin-6 (IL-6) using ELISA; Western blotting was used to detect the expression of SIRT1 and nuclear factor- κB (NF-κB) in the hippocampal neurons. RESULTS: < 0.05). CONCLUSIONS: DEX alleviates POCD in aged rats probably via SIRT1 signaling pathway.

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Available abstract

OBJECTIVE: To explore the role of silent information regulator 1 (SIRT1) signaling pathway in mediating the effect of dexmedetomidine (DEX) to alleviate postoperative cognitive dysfunction (POCD) in aged rats. METHODS: ) and interleukin-6 (IL-6) using ELISA; Western blotting was used to detect the expression of SIRT1 and nuclear factor- κB (NF-κB) in the hippocampal neurons. RESULTS: < 0.05). CONCLUSIONS: DEX alleviates POCD in aged rats probably via SIRT1 signaling pathway.

Key concepts: Postoperative cognitive dysfunction, Hippocampal formation, Hippocampus, Medicine, Morris water navigation task, Dexmedetomidine, Saline, Tumor necrosis factor alpha

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