2019•New England Journal of MedicineRequires access

Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides

Varman T. Samuel, Gerald I. Shulman

Abstract

Insulin resistance is a precursor to and accelerant of coexisting conditions such as type 2 diabetes, atherosclerosis, and nonalcoholic liver disease. A recent study of mouse models implicates elevated levels of ceramide and their effect on mitochondrial function in the mediation of cellular insulin resistance.

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Key concepts: Nonalcoholic fatty liver disease, Insulin resistance, Medicine, Ceramide, Type 2 diabetes, Internal medicine, Endocrinology, Disease