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2015•Unpublished venueOpen access

Author response: The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

Carmela Sidrauski, Anna M. McGeachy, Nicholas T. Ingolia, Peter Walter

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Abstract

Building on previous work which showed that the small molecule ISRIB potently blocks the integrated stress response (Sidrauski et al., 2013), we report on ISRIB's remarkable specificity and fast action in vivo, underscoring its proposed direct effect on translation.

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What this paper is about

Building on previous work which showed that the small molecule ISRIB potently blocks the integrated stress response (Sidrauski et al., 2013), we report on ISRIB's remarkable specificity and fast action in vivo, underscoring its proposed direct effect on translation.

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OpenAlex reports 5 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Building on previous work which showed that the small molecule ISRIB potently blocks the integrated stress response (Sidrauski et al., 2013), we report on ISRIB's remarkable specificity and fast action in vivo, underscoring its proposed direct effect on translation.

Key concepts: Integrated stress response, Stress granule, Phosphorylation, eIF2, Eukaryotic initiation factor, Translational regulation, Eukaryotic translation, Ribosome profiling

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Author response: The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly — Research Paper | ScholarLens