2019•Cancer DiscoveryRequires access

Dendritic Cells Drive Osteosarcomagenesis through Newly Identified Oncogene and Tumor Suppressor

Kevin B. Jones

Abstract

Abstract Summary: GRM4, a GWAS-suspected tumor suppressor, is tested in a mouse model of osteosarcomagenesis as well as the putative oncogene it suppresses, IL23. Both are expressed in and exert the bulk of their influence among tumor-infiltrating myeloid-derived antigen-presenting cells, rather than osteosarcoma cells. See related article by Kansara et al., p. 1511.

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Available abstract

Key concepts: Suppressor, Oncogene, Cancer research, Myeloid-derived Suppressor Cell, Biology, Osteosarcoma, Antigen, Myeloid