Lipid Peroxidation and the Kidney

Lipid peroxidation involves the production of semistable peroxides from free radical intermediates produced by direct reaction of oxygen with unsaturated lipid. Cephaloridine increased the in vitro peroxidation of rat kidney microsomal lipids in a concentration- and time-dependent manner. C. H. Kuo et al. have suggested that lipid peroxidation might be associated with cephaloridine toxicity in the renal cortex. C. J. Green and associates were able to demonstrate an increased susceptibility to lipid peroxidation in rabbit kidneys, which was a consequence of warm ischemia and subsequent reperfusion. One attractive hypothesis relates to the activation by ischemia of toxins or endogenous lipases which then enzymatically cleave polyunsaturated fatty acids from phospholipids. G. B. Ryan and M. J. Karnovsky examined the efficacy of oxygen free radical and xanthine oxidase inhibition to diminish the proteinuria of aminonucleoside nephrosis in the rat. D. A. Troy et al. have demonstrated lipid alterations in LLCPK-1 cells in culture exposed to mercuric chloride.