Glycopeptide and Oligosaccharide Libraries
Phaedria M. St. Hilaire, Morten Meldal
Abstract
Phaedria M. St. Hilaire, Morten Meldal
Abstract
This chapter contains sections titled: Parallel Arrays versus Libraries of Compounds Proteins Recognising Carbohydrates The Carbohydrate Ligands Supports for Solid-Phase Libraries Analytical Tools for Oligosaccharide and Glycopeptide Libraries Introduction to Array and Library Synthesis of Oligosaccharides Parallel Synthesis of Oligosaccharide Arrays Synthesis of Oligosaccharide Libraries Glycopeptide Templates as Oligosaccharide Mimetics Parallel Synthesis of Glycopeptide Arrays Preparation and AnaIysis of Solid-Phase Clycopeptide Template Libraries Screening of a Solid-Phase Glycopeptide Library Conclusions Acknowledgements References
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This chapter contains sections titled: Parallel Arrays versus Libraries of Compounds Proteins Recognising Carbohydrates The Carbohydrate Ligands Supports for Solid-Phase Libraries Analytical Tools for Oligosaccharide and Glycopeptide Libraries Introduction to Array and Library Synthesis of Oligosaccharides Parallel Synthesis of Oligosaccharide Arrays Synthesis of Oligosaccharide Libraries Glycopeptide Templates as Oligosaccharide Mimetics Parallel Synthesis of Glycopeptide Arrays Preparation and AnaIysis of Solid-Phase Clycopeptide Template Libraries Screening of a Solid-Phase Glycopeptide Library Conclusions Acknowledgements References
Key concepts: Glycopeptide, Oligosaccharide, Solid-phase synthesis, Chemistry, Template, Biochemistry, Combinatorial chemistry, Computer science