Changing Characteristics of Extravascular Lung Water After Fluid Resuscitation in Septic Shock Patients by Early PiCCO Monitoring

This study aims to explore the changing characteristics of extravascular lung water after fluid resuscitation in septic shock patients by early PiCCO monitoring. 42 patients who were admitted to the ICU in our hospital and diagnosed as septic shock were collected. The patients were divided into two groups: treatment group (PiCCO group) (n=21) and control group (CVP group) (n=21). They were given early fluid resuscitation using different monitoring methods on the basis of conventional treatment for septic shock to monitor the changes of hemodynamics, EVLWI, oxygenation index (PaO2/FiO2) and BNP level before and after resuscitation. The BNP and LAC levels of the treatment group were significantly lower than those of the control group within 72 h (P<0.05). The use time of vasoactive drug, duration of mechanical ventilation and length of stay in ICU were significantly shorter in the treatment group than those in the control group (P<0.05), but there were no significant differences in the incidence of MODS and mortality between the two groups (P>0.05). ITBVI and GEDVI immediately, 12 h and 24 h after the fluid resuscitation were increased in the two groups compared with those before, between which the difference was statistically significant (P<0.01). Compared with those before resuscitation, the differences in PaO2/FiO2 at each time point in the two groups were not statistically significant (P>0.05). Early fluid resuscitation under the guidance of PiCCO has significant effect, which can be used as one of indicators for hemodynamic monitoring.