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피부질환에서 Involucrin과 Filaggrin의 발현에 대한 면역조직화학적 연구
이승철, 이지범, 서재정, 박진영, 원영호
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Abstract
Background: The cornified cell envelope (CE) is a unique structure found in the terminal differentiation of the skin. The precursor proteins of the CE are composed of many candidate structural proteins, among which invalucrin and filaggrin are important ones to participate in the complicated process of forming, the complex structure. Objective: The purpose of this study was to evaluate the usefulness of expression of involucrin and filaggrin as markers of terminal differentiation in various skin disorders including tumors. Methods: Immunohistochemical studies were performed in the formalin-fixed, paraffin-embedded skin samples of non-tumors (41 cases) and tumors (43 cases). (continue...) (Korean J Dermatol 199~9;37(6): 708-714)