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[Expression of Serum HMGB1 and CD14+ mononuclear Toll-like Receptors in Children with Hemophagocytic Syndrome and Their Effect on Prognosis].

Simin Zhang, Min Wang, Zhi Chen, Xiaofang Cai

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Abstract

OBJECTIVE: monocyte Toll-like receptors in children with hemophagocytic syndrome (HPS), and to analyze its effect on the prognosis of children. METHODS: monocytes, the ELISA was used to detect the expression of HMGB1 in serum of peripheral blood. The relationship of TLR2, TLR4, TLR6 and HMGB1 expression with the clinical parameters, short-term therapentic efficacy and prognosis was analyzed, the relation of TLR2, TLR4 and TLR6 expression with HMGB1 also was analyzed. RESULTS: monocytes (P＜ 0.05). CONCLUSION: monocytes in HPS children are significantly higher than those in healthy children.The expression levels of TLR2, TLR4, and TLR6 positively correlate with serum HMGB1 content, which provides reference for the diagnosis and prognosis of children with HPS.

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What this paper is about

OBJECTIVE: monocyte Toll-like receptors in children with hemophagocytic syndrome (HPS), and to analyze its effect on the prognosis of children. METHODS: monocytes, the ELISA was used to detect the expression of HMGB1 in serum of peripheral blood. The relationship of TLR2, TLR4, TLR6 and HMGB1 expression with the clinical parameters, short-term therapentic efficacy and prognosis was analyzed, the relation of TLR2, TLR4 and TLR6 expression with HMGB1 also was analyzed. RESULTS: monocytes (P＜ 0.05). CONCLUSION: monocytes in HPS children are significantly higher than those in healthy children.The expression levels of TLR2, TLR4, and TLR6 positively correlate with serum HMGB1 content, which provides reference for the diagnosis and prognosis of children with HPS.

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Available abstract

OBJECTIVE: monocyte Toll-like receptors in children with hemophagocytic syndrome (HPS), and to analyze its effect on the prognosis of children. METHODS: monocytes, the ELISA was used to detect the expression of HMGB1 in serum of peripheral blood. The relationship of TLR2, TLR4, TLR6 and HMGB1 expression with the clinical parameters, short-term therapentic efficacy and prognosis was analyzed, the relation of TLR2, TLR4 and TLR6 expression with HMGB1 also was analyzed. RESULTS: monocytes (P＜ 0.05). CONCLUSION: monocytes in HPS children are significantly higher than those in healthy children.The expression levels of TLR2, TLR4, and TLR6 positively correlate with serum HMGB1 content, which provides reference for the diagnosis and prognosis of children with HPS.

Key concepts: CD14, Medicine, TLR2, Receptor, Internal medicine, HMGB1, Peripheral blood mononuclear cell, TLR4

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[Expression of Serum HMGB1 and CD14+ mononuclear Toll-like Receptors in Children with Hemophagocytic Syndrome and Their Effect on Prognosis]. — Research Paper | ScholarLens