2017•PubMedRequires access
[Promoting effect of cyclin D1 overexpression on proliferation and epithelial mesenchymal transition of cervical squamous cell carcinoma SiHa cells].
P Wang, S Liu, Brian Cheng, Xue-Zhi Wu, Siqing Ding, Liyun Xu, Y Liu, Li Duan, Shixiong Sun
Open publisher page 3 citations
Abstract
Overexpression of cyclin D1 induced by gene transfection promotes proliferation and epithelial mesenchymal transition in SiHa cells.The process is accompanied by up-regulation of CDK4, CDK2, p21, p27 and cyclin E genes.p21 expression increases synchronously with cyclin D1, suggesting a regulatory role in epithelial mesenchymal transition by affecting expression of vimentin in G-3 cells.