[Homeostasis and Disorder of Musculoskeletal System.Molecular mechanism underlying muscle development and regeneration.]

Skeletal muscle composes 30-40% of our body weight and is formed by multinuclear cells called myofibers. The formation of myofiber depends on the dynamic proliferation, differentiation and fusion of the myogenic progenitors during development. In the adult stage, the skeletal muscle exhibits excellent regeneration ability as well, depended on the muscle stem(satellite)cells that generate and repair myofibers. In this review, we would like to introduce ① the mechanisms of myogenic progenitor-dependent myofiber formation in myogenesis, ② the common fusion mechanism for myogenesis and muscle regeneration, and ③ the current status and prospects for clinical application utilizing satellite cells.