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[Genotype Analysis of Patients with Thalassemia in Sanya Area of Hainan Province in China].

Mengi Li, Song-He Xiang, Yi� Ding, Wenwen Liu, Yuanyuan Xu, Jian Bo

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Abstract

OBJECTIVE: To explore the frequency and spectrum of thalassemia gene mutations of the population in Sanya area of Hainan province in China. METHODS: The type and frequency of gene mutation in 1060 patients with suspected thalassemia were analyzed by Gap-PCR and reverse dot blot (RDB). RESULTS: /αα genotype (0.94%). CONCLUSION: The data of this study provide the frequency and the spectrum of thalassemia gene mutations in the sanya area of Hainan province, which can contribute to set up the strategies for the prevention and control of thalassemia in this area.

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What this paper is about

OBJECTIVE: To explore the frequency and spectrum of thalassemia gene mutations of the population in Sanya area of Hainan province in China. METHODS: The type and frequency of gene mutation in 1060 patients with suspected thalassemia were analyzed by Gap-PCR and reverse dot blot (RDB). RESULTS: /αα genotype (0.94%). CONCLUSION: The data of this study provide the frequency and the spectrum of thalassemia gene mutations in the sanya area of Hainan province, which can contribute to set up the strategies for the prevention and control of thalassemia in this area.

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Available abstract

OBJECTIVE: To explore the frequency and spectrum of thalassemia gene mutations of the population in Sanya area of Hainan province in China. METHODS: The type and frequency of gene mutation in 1060 patients with suspected thalassemia were analyzed by Gap-PCR and reverse dot blot (RDB). RESULTS: /αα genotype (0.94%). CONCLUSION: The data of this study provide the frequency and the spectrum of thalassemia gene mutations in the sanya area of Hainan province, which can contribute to set up the strategies for the prevention and control of thalassemia in this area.

Key concepts: Thalassemia, Genotype, Genetics, Medicine, Gene, Internal medicine, Traditional medicine, Biology

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