2019•Antimicrobial Agents and ChemotherapyOpen access

High-Level Carbapenem Resistance in OXA-232-Producing Raoultella ornithinolytica Triggered by Ertapenem Therapy

Alina Iovleva, Roberta T. Mettus, Christi L. McElheny, M. Patrick Griffith, Mustapha M. Mustapha, A. William Pasculle, Ryan K. Shields, Vaughn S. Cooper, Yohei Doi

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Abstract

OXA-232 is an OXA-48-group class D β-lactamase that hydrolyzes expanded-spectrum cephalosporins and carbapenems at low levels. Clinical strains producing OXA-232 are sometimes susceptible to carbapenems, making it difficult to identify them in the clinical microbiology laboratory.

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Key concepts: Ertapenem, Carbapenem, Meropenem, Microbiology, Cephalosporin, Biology, Complementation, Carbapenem-resistant enterobacteriaceae