Cell Cycle Dynamics and Endoreplication In the Mosquito Midgut

The mosquitoes are the major transmissors of vector-borne infections, including virus, protozoans and helminths and, during the interaction it is critical for pathogens to accomplish immune evasion actions whereas the mosquito turn on immune mechanisms for its survival. The mosquito midgut is the organ where initial interactions with pathogens happen, and the insect has mechanisms to repair the tissue and to eliminate the invaders. For these tasks’ mosquitoes use different strategies including the specific DNA replication, amplifying specific genes and without cell division in order to have more DNA templates for transcription that allow, in a secondary infection, the fast production of immune proteins in a process known as priming. The study of these processes is necessary for the understanding of the mechanisms during insect-pathogens interactions, and to design future interventions to block mosquito pathogens transmission that could be environment-friendly and not depending on costly chemicals.