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2018•PubMedRequires access

No effect of MTP polymorphisms on PNPLA3 in HCV-correlated steatosis.

Rosa Zampino, Margherita Macera, Grazia Cirillo, Pia Clara Pafundi, Luca Rinaldi, Nicola Coppola, Mariantonietta Pisaturo, Luigi Elio Adinolfi, Emanuele Miraglia del Giudice, Diego Ingrosso, Rosanna Capasso

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Abstract

PNPLA3 and MTP genes have been associated with liver steatosis and chronic hepatitis C. We studied the influence of MTP and PNPLA3 polymorphisms in 114 Italian patients with chronic hepatitis C, evaluating the histological and clinical presentation of liver disease. The study confirmed the association of PNPLA3 polymorphisms with liver steatosis (p=0.041), but did not show any additive effect of MTP polymorphisms in the development of steatosis. MTP polymorphisms do not seem to influence PNPLA3 in the development of liver steatosis. Further studies with a larger number of patients are required.

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What this paper is about

PNPLA3 and MTP genes have been associated with liver steatosis and chronic hepatitis C. We studied the influence of MTP and PNPLA3 polymorphisms in 114 Italian patients with chronic hepatitis C, evaluating the histological and clinical presentation of liver disease. The study confirmed the association of PNPLA3 polymorphisms with liver steatosis (p=0.041), but did not show any additive effect of MTP polymorphisms in the development of steatosis. MTP polymorphisms do not seem to influence PNPLA3 in the development of liver steatosis. Further studies with a larger number of patients are required.

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Available abstract

PNPLA3 and MTP genes have been associated with liver steatosis and chronic hepatitis C. We studied the influence of MTP and PNPLA3 polymorphisms in 114 Italian patients with chronic hepatitis C, evaluating the histological and clinical presentation of liver disease. The study confirmed the association of PNPLA3 polymorphisms with liver steatosis (p=0.041), but did not show any additive effect of MTP polymorphisms in the development of steatosis. MTP polymorphisms do not seem to influence PNPLA3 in the development of liver steatosis. Further studies with a larger number of patients are required.

Key concepts: Steatosis, Liver steatosis, Chronic hepatitis, Gastroenterology, Internal medicine, Medicine, Single-nucleotide polymorphism, Fatty liver

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No effect of MTP polymorphisms on PNPLA3 in HCV-correlated steatosis. — Research Paper | ScholarLens