Effect of tirofiban on no-reflow phenomenon during primary percutaneous coronary intervention in patients with acute myocardial infarction

Objective To evaluate the effect of platelet GPⅡb/Ⅲa antagonist Tirofiban on no-reflow phenomenon during primary percutaneous coronary intervention(PCI) in patients with ST segment elevation acute myocardial infarction(STEAMI).Methods One hundred and four STEAMI patients who underwent primary PCI in Harbin Medical University from Jan 2006 To Dec 2006 were enrolled.Patients were divided randomly into two groups: Tirofiban group and control(without Tirofiban) group.TIMI flow grade after PCI and complete ST segment resolution at 24 hours and one week later were analyzed.The composite primary end point event and bleeding complication at 24 hours and 30 days were also recorded. Results In tirofiban group,92.3% patients were recovered with TIMI 3 grade flow after PCI and 7.7% of patients were recovered with TIMI 0-2 grade flow;in control group,80.7% of patients restored TIMI 3 grade and 19.3% of patients were recovered with TIMI 0-2 grade flow.The difference was statistically significant(P0.05).Rate of complete ST resolution was higher in Tirofiban group than in control group(P0.05).Composite primary end point events and bleeding complication at 24 hours and 30 days were not significantly different between Tirofiban group and control group. Conclusions Tirfiban used during PCI treatment for STEAMI can effectively prevent no-reflow phenomenon.