Clinical distribution and antimicrobial resistance of 172 Proteus mirabilis isolates and 68 Proteus vulgaris isolates

Objective To analyze strains of Proteus mirabilis(P.mirabilis)and Proteus vulgaris(P.vulgaris)isolated in a hospital,detect resistance to commonly used antimicrobial agents,and provide reference for rational application of antimicrobial agents in clinic.Methods 172 P.mirabilis isolates and 68 P.vulgaris isolates isolated between January 1,2011 and June 30,2013 were analyzed,antimicrobial resistance susceptibility testing were performed by disk diffusion method,data were analyzed with WHONET5.4 software.Results P.mirabilis strains were mainly isolated from wound secretion(26.74%),sputum(22.68%)and urine(18.61%),P.vulgaris were mainly from wound secretion(48.53%),urine(17.65%)and sputum(11.77%).The resistance rates of P.mirabilis to ampicillin and trimethoprim/sulfamethoxazole were both45.00%;the resistance rates of P.vulgaris to cefazolin and trimethoprim/sulfamethoxazole was 86.76% and 41.18% respectively;the resistance rates of P.mirabilis and P.vulgaris to piperacillin/tazobactam,cefotaxime,ceftazidime,cefepime,carbapenems(ertapenem and meropenem)and amikacin were all20.00%.Conclusion The resistance rates of P.mirabilis and P.vulgaris to piperacillin/tazobactam,cefotaxime,ceftazidime,cefepime,ertapenem,meropenem and amikacin are all high,and can be used as the empirical medication for the treatment of related infection.