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2013•Journal of Chinese Pharmaceutical SciencesOpen access

Two new furostanol glycosides from Asparagus cochinchinensis (Lour.) Merr.

Rui Jian, Pengfei Tu

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Abstract

Two new furostanol glycosides, aspacochinosides L (1) and M (2), were isolated from the roots of Asparagus cochinchinensis (Lour.) Merr. Their structures were determined by chemical methods and NMR spectral analysis, including extensive 1D and 2D NMR experiments. Compounds 1 and 2 were investigated for their anti-neuroinflammatory activity in LPS-induced BV-2 cells. Compound 2 showed moderate inhibitory effect on NO production in LPS-induced BV-2 microglial cells with IC50 value of 32.26 μM.

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Two new furostanol glycosides, aspacochinosides L (1) and M (2), were isolated from the roots of Asparagus cochinchinensis (Lour.) Merr. Their structures were determined by chemical methods and NMR spectral analysis, including extensive 1D and 2D NMR experiments. Compounds 1 and 2 were investigated for their anti-neuroinflammatory activity in LPS-induced BV-2 cells. Compound 2 showed moderate inhibitory effect on NO production in LPS-induced BV-2 microglial cells with IC50 value of 32.26 μM.

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Available abstract

Two new furostanol glycosides, aspacochinosides L (1) and M (2), were isolated from the roots of Asparagus cochinchinensis (Lour.) Merr. Their structures were determined by chemical methods and NMR spectral analysis, including extensive 1D and 2D NMR experiments. Compounds 1 and 2 were investigated for their anti-neuroinflammatory activity in LPS-induced BV-2 cells. Compound 2 showed moderate inhibitory effect on NO production in LPS-induced BV-2 microglial cells with IC50 value of 32.26 μM.

Key concepts: Asparagus, Traditional medicine, Glycoside, Chemistry, Botany, Biology, Medicine

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