Effect of dexmedetomidine on stress reaction caused by double-lumen endotracheal intubation in hypertension patients

AIM To study the effect of dexmedetomidine on the stress reaction caused by double-lumen endotracheal intubation in hypertension patients.METHODS Forty ASA Ⅱ-Ⅲ with hypertension scheduled general anesthesia with double-lumen endotracheal intubation,aged 50-65 years old,were randomly divided into two groups(n = 20 each).In the dexmedetomidine group,10 min before anesthesia induction,dexmedetomidine 1 μg.kg-1 was infused over 10 min.The equal volume of normal saline was given in the control group.The mean arterial pressure(MAP),heart rate(HR),the plasma concentration of epinephrine(E) and norepinephrine(NE) were detected and recorded before anesthesia(T 0),intubation succeed(T 1),1 min after intubation(T 2),5 min after intubation(T 3) and 10 min after intubation(T 4).The adverse reactions were also observed.RESULTS Compared with those at T 0,MAP,HR and the concentration of E,NE at T 1-T 4 in the control group were increased(P 0.05).And the concentration of E,NE at T 2 in the dexmedetomidine group were higher those at T 0(P 0.05).Compared with those in the control group,MAP,HR and the concentration of E,NE in the dexmedetomidine group were decreased at T 1-T 4(P 0.05).NO obvious adverse reactions occurred in both groups.CONCLUSION Dexmedetomidine can inhibit the stress reaction caused by double-lumen endotracheal intubation effectively and maintain hemodynamics stabilize in hypertension patients.