Recent Advances and Application of Pharmacokinetic-pharmacodynamic(PK-PD) Modeling

OBJECTIVE To review the advances on pharmacokinetic-pharmacodynamic(PK-PD) modeling.METHODS On the basis of analysing and concluding the relevant articles for the last ten years,the types,programs and application of PK-PD modeling were summarized.RESULTS There are four kinds of pharmacokinetic-pharmacodynamic(PK-PD) modeling,which were widely applied on drug development,individual administration and clinical detection,providing useful information to guide clinical medication.CONCLUSION PK-PD modeling has been improved and plays important role in drug development with its deep study.