Relationship among plasma omentin,apelin and metabolic syndrome

Objective:To study the relationship among omentin,apelin and metabolic syndrome(MS) by observing plasma levels of both in MS patients.Methods:According to the 2005 international diabetes federation(IDF) criteria for MS diagnosis,a total of 64 MS patients(MS group) were enrolled,and another 45 healthy people were enrolled as normal control group at the same time.Blood pressure,body mass index(BMI),smoking history and family history were collected in all subjects.And blood glucose,blood lipid,hepatic and renal function were measured.Enzyme linked immunosorbent assay was used to measured plasma concentrations of omentin and apelin.Results:(1) Age,sex ratio and height showed no significant difference between the two groups(P0.05);weight,circumference,BMI,levels of blood pressure,fasting plasma glucose(FPG),blood lipid in MS group were significantly higher than those of normal control group(P0.05～0.01);(2) There was no significant difference in plasma apelin level [(1.05±0.60)ng/ml vs.(0.90±0.31)ng/ml,P0.05] between the two groups;plasma level of omentin in MS group significantly decreased compared with that of normal control group [(31.73±24.66) ng/ml vs.(46.83±21.83) ng/ml,P0.001];(3) Relative analysis showed that plasma level of apelin was positively correlated with FPG(r=0.5852,P0.05);Plasma level of omentin was negatively correlated with weight(r=0.6079,P0.05),plasma level of omentin was negatively correlated with level of apelin(r=-0.3354,P=0.024).Conclusion:Apelin and omentin may take part in certain metabolism course in metabolic syndrome.