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2019•Unpublished venueOpen access

ASSOCIATION BETWEEN JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS AND RENAL THROMBOTIC MICROANGIOPATHY: CASE REPORT

MIKAEL ALBUQUERQUE DO BÚ, ALINE CORDEIRO DE AZEVÊDO, ANA AMÉLIA SOARES DE LIMA, JULIANA CLEMENTE DO RÊGO, Lucas de Moura Brito, RENNAN LOUREIRO BATISTA MARINHO, Sofia Nunes Pinto De Oliveira, WILKER JOHN BARRETO, Marcus Ivanovith Fernandes, Evânia Claudino Queiroga de Figueiredo

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Abstract

Thrombotic microangiopathy (TMA) is characterized by a clinical presentation composed by thrombocytopenia, microangiopathic hemolytic anemia and organ damage. It may be manifested through several presentations, including acute kidney injury, which is a common feature due to the apparent propensity of the glomerular circulation to endothelial damage and occlusion. Regarding systemic lupus erythematosus, thrombotic microangiopathy is reported in 8%-15% of the biopsies performed in patients with this autoimmune disease. The pathogenic mechanisms related to this specific situation are still unknown and the treatment to be performed is the one specific to lupus.

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Thrombotic microangiopathy (TMA) is characterized by a clinical presentation composed by thrombocytopenia, microangiopathic hemolytic anemia and organ damage. It may be manifested through several presentations, including acute kidney injury, which is a common feature due to the apparent propensity of the glomerular circulation to endothelial damage and occlusion. Regarding systemic lupus erythematosus, thrombotic microangiopathy is reported in 8%-15% of the biopsies performed in patients with this autoimmune disease. The pathogenic mechanisms related to this specific situation are still unknown and the treatment to be performed is the one specific to lupus.

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Available abstract

Thrombotic microangiopathy (TMA) is characterized by a clinical presentation composed by thrombocytopenia, microangiopathic hemolytic anemia and organ damage. It may be manifested through several presentations, including acute kidney injury, which is a common feature due to the apparent propensity of the glomerular circulation to endothelial damage and occlusion. Regarding systemic lupus erythematosus, thrombotic microangiopathy is reported in 8%-15% of the biopsies performed in patients with this autoimmune disease. The pathogenic mechanisms related to this specific situation are still unknown and the treatment to be performed is the one specific to lupus.

Key concepts: Thrombotic microangiopathy, Microangiopathy, Microangiopathic hemolytic anemia, Medicine, Pathology, Schistocyte, Lupus nephritis, Thrombotic thrombocytopenic purpura

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ASSOCIATION BETWEEN JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS AND RENAL THROMBOTIC MICROANGIOPATHY: CASE REPORT — Research Paper | ScholarLens