2013•Wageningen Academic Publishers eBooksRequires access
First evidence of an insulin-sensitive glucose transporter in chicken: GLUT-12
Edouard Coudert, Joëlle Dupont, Joe J. Simon, Estelle Cailleau-Audouin, Sabine Crochet, Michel Jacques M.J. Duclos, Sophie Tesseraud, Sonia Métayer-Coustard
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Abstract
Facilitated transport of glucose into cells is mediated by a family of facilitative-diffusion glucose transporter (GLUT) proteins. In mammals, mostly in adipose and muscle tissues, some GLUTs, called ‘insulin-sensitive GLUTs’, are recruited at the plasma membrane in response to insulin. Facilitative-diffusion glucose transporter-4 is the best characterized (Bryant et al., 2002). So far, no functional ‘insulin-sensitive GLUTs’ has been characterized in chicken tissues. This species exhibits some peculiarities for glucose metabolism: a high glycaemia despite the presence of insulin circulating at ‘normal’ concentrations, and a low sensitivity to exogenous insulin, reminiscent of mammalian type-2 diabetes.