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2019•Science SignalingOpen access

Structure-function guided modeling of chemokine-GPCR specificity for the chemokine XCL1 and its receptor XCR1

Jamie C. Fox, Monica A. Thomas, Acacia F. Dishman, Olav Larsen, Takashi Nakayama, Osamu Yoshie, METTE MARIE ROSENKILDE, Brian F. Volkman

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Abstract

led to diminished binding and activation of XCR1 by XCL1. These findings demonstrate the utility of a hybrid approach, using biological data and homology modeling, to study chemokine-GPCR interactions.

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led to diminished binding and activation of XCR1 by XCL1. These findings demonstrate the utility of a hybrid approach, using biological data and homology modeling, to study chemokine-GPCR interactions.

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Available abstract

led to diminished binding and activation of XCR1 by XCL1. These findings demonstrate the utility of a hybrid approach, using biological data and homology modeling, to study chemokine-GPCR interactions.

Key concepts: Chemokine receptor, C-C chemokine receptor type 6, CCL21, XCL2, CC chemokine receptors, Chemokine, Chemistry, G protein-coupled receptor

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