2019•Antimicrobial Agents and ChemotherapyOpen access
Novel 5-Nitrofuran-Activating Reductase in Escherichia coli
Vuong Van Hung Le, Ieuan G. Davies, Christina D. Moon, David Wheeler, Patrick J. Biggs, Jasna Rakonjac
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Abstract
The global spread of multidrug-resistant enterobacteria warrants new strategies to combat these pathogens. One possible approach is the reconsideration of “old” antimicrobials, which remain effective after decades of use. Synthetic 5-nitrofurans such as furazolidone, nitrofurantoin, and nitrofurazone are such a class of antimicrobial drugs.