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2019•European Journal of Medicinal ChemistryOpen access

Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors

Romeo Romagnoli, Paola Oliva, María Kimatrai Salvador, M. Encarnación Camacho, Chiara Padroni, Andrea Brancale, Salvatore Ferla, Ernest Hamel, Roberto Ronca, Elisabetta Grillo, Roberta Bortolozzi, Fatlum Rruga, Elena Mariotto, Giampietro Viola

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Key concepts: Pyrazole, Chemistry, Moiety, Combretastatin, Stereochemistry, Tubulin, Ring (chemistry), Aryl

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Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors — Research Paper | ScholarLens